MyBioSource.com's USP44 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot. The USP44 Antibody was generated using USP44 as the antigen and it reacts with Human, and Mouse.
Description
Function: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
Post-translational Modifications: Dephosphorylated by CTDP1. Ubiquitinated; undergoes both 'Lys-48'-and 'Lys-63'-linked polyubiquitination and is degraded by the proteasome.
Similarity: Belongs to the peptidase C19 family. USP44 subfamily